Target Synonym: SEC61B; Sec61 translocon beta subunit
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunogen: A synthetic peptide of human SEC61B
Dilution: WB 1:500-1:2000;IF 1:50-1:200
Calculated MW: 9kDa
Observed MW: Refer to figures
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