Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-benzamide
Purity: ≥95%
Formula Markup: C24H24FN7O
Formula Weight: 445.492343
CAS Number: 1448428-04-3
Notes: Selonsertib is an inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 5.01 nM).{63340} It decreases apoptosis and stellate cell activation in an in vitro 3D-human liver microtissue model of non-alcoholic steatohepatitis (NASH) induced by palmitic acid (Item No. 10006627) when used at a concentration of 1 µM.{63341} Selonsertib (10 µM) sensitizes KB-C2 epidermoid carcinoma cells, which endogenously express ATP-binding cassette family B member 1 (ABCB1), to doxorubicin (Item No. 15007) and paclitaxel (Item No. 10461).{63342} It reduces hepatic necrosis and increases in serum TNF-α, IL-6, and chemokine (C-C motif) ligand 2 (CCL2) levels in a mouse model of LPS/D-galactosamine-induced acute liver failure when administered at doses of 15, 30, or 60 mg/kg.{63343}
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