Product Description: Sepantronium bromide (YM-155) is a survivin inhibitor with an IC50 of 0.54 nM[1].
Applications: Cancer-programmed cell death
Formula: C20H19BrN4O3
References: [1]Nakahara T, et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007 Sep 1;67(17):8014-21./[2]Iisa T, et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res. 2008 Oct 15;14(20):6496-504./[3]Guo K, et al. A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model. Oncotarget. 2015 Aug 28;6(25):21137-47.
CAS Number: 781661-94-7
Molecular Weight: 443.29
Compound Purity: 99.36
Research Area: Cancer
Solubility: DMSO : 11.67 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 50 mg/mL (ultrasonic)
Target: Autophagy;Survivin
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