Product Description: SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.
Applications: Cancer-programmed cell death
Formula: C27H23N7O
References: [1]Datta J, et al. A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res. 2009 May 15;69(10):4277-85./[2]Rilova E, et al. Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation. ChemMedChem. 2014 Mar;9(3):590-601.
CAS Number: 1020149-73-8
Molecular Weight: 461.52
Compound Purity: 99.92
Research Area: Cancer
Solubility: DMSO : 27 mg/mL (ultrasonic;warming)
Target: Apoptosis;DNA Methyltransferase
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