SHANK1/SHANK3 Antibody, Clone N367/51: ATTO 488

Mouse Anti-Rat SHANK1/SHANK3 Monoclonal IgG2a

Target: SHANK3

Conjugate: ATTO 488

Product Type: Monoclonal

Clone Number: N367/51 (Formerly sold as S367-51)

Immunogen: Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ~70% identity with SHANK1 and SHANK2.

Swiss-Prot: Q9JLU4

Purification: Protein G Purified

Storage Buffer: 640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Concentration: 1 mg/ml

Specificity: Detects ~190kDa. Cross-reacts with SHANK1. Does not cross-react with SHANK2.

Cellular Localization: Cytoplasm / Cell Junction

Scientific Background: SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSMC-460D-A488
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SMC-460D-A488
• Package Unit: 100 µg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Monoclonal
• Application: Immunofluorescence, Immunohistochemistry, Immunocytochemistry
• Isotype: IgG2a
• Human Gene ID: 59312
• Host: Mouse
• Conjugate: Conjugated, Atto 488