Background: Calreticulin, a Ca2+ chaperone, is an abundant highly conserved calcium binding protein found in the lumen of the endoplasmic reticulum of eukaryotic cells. This lumen protein can be used to measure the intactness of membrane preparations. It is used as a marker for subcellular fractionation of cells.
Positive Control: MDCK cells; MCF-7 cells.
Purification Method: Ammonium Sulfate Precipitation.
Source: Sheep were immunized with a recombinant protein derived from the carboxy terminus of the calreticulin protein fused to KLH.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Kageyama, S., et al. 'Urinary calreticulin in the diagnosis of bladder urothelial carcinoma.' Int. J. Urol. 2009, 16, 481-486
2. Silerova, M., et al. 'Characterization, molecular cloning and localization of calreticulin in Eisenia fetida earthworms.' Gene 2007, 397, 169-177
3. Souto-Padron, T., et al. 'Immunocytochemical localisation of calreticulin in Trypanosoma cruzi.' Histochem. Cell Biol. 2004, 122, 563-569.
UniProt: Q6IAT4 (Human)
P14211 (Mouse)
P18418 (Rat)
P28490 (Dog).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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