Simvastatin acid (ammonium), CAS 139893-43-9

Product Description: Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C25H43NO6

References: [1]Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272./[2]Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165.

CAS Number: 139893-43-9

Molecular Weight: 453.61

Compound Purity: 99.70

Research Area: Inflammation/Immunology; Cardiovascular Disease

Solubility: DMSO : 7 mg/mL (ultrasonic;warming;heat to 60°C)

Target: HMG-CoA Reductase (HMGCR);Reactive Oxygen Species

• SKU: MEXHY-119695A-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-119695A-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK