Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,2-di(methyl-d3)-butanoic acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C25H32D6O5
Formula Weight: 424.6
CAS Number: 1002347-71-8
Notes: Simvastatin-d6 is intended for use as an internal standard for the quantification of simvastatin (Item Nos. 10010344 / 10010345) by GC- or LC-MS. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM).{15312} Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively.{15310} Simvastatin suppresses TNF-induced NF-κB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid leukemia cells.{15363} It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells.{62465} Formulations containing simvastatin have been used in the treatment of dyslipidemias.
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