Simvastatin hydroxy acid (sodium), CAS 101314-97-0

Product Description: Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

Applications: Cancer-programmed cell death

Formula: C25H39NaO6

References: [1]Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272./[2]Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165.

CAS Number: 101314-97-0

Molecular Weight: 458.56

Compound Purity: 99.86

Research Area: Inflammation/Immunology; Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: HMG-CoA Reductase (HMGCR);Reactive Oxygen Species

• SKU: MEXHY-115292-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-115292-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK