Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (ßR,dR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-ß,d-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monosodium salt
Purity: ≥98%
Formula Markup: C25H39O6 / Na
Formula Weight: 458.6
CAS Number: 101314-97-0
Notes: Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM).{15312} Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively.{15310} Simvastatin suppresses TNF-induced NF-κB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid leukemia cells.{15363} It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells.{62465} Formulations containing simvastatin have been used in the treatment of dyslipidemias.
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