Product Description: Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].
Applications: COVID-19-anti-virus
Formula: C15H23N7O5
References: [1]Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7./[2]Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1):203-15.
CAS Number: 58944-73-3
Molecular Weight: 381.39
Compound Purity: 99.91
Research Area: Infection; Inflammation/Immunology
Solubility: H2O : 100 mg/mL (ultrasonic)
Target: Antibiotic;Fungal;Histone Methyltransferase;Parasite
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