SJ 172550, CAS 431979-47-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid, methyl ester

Purity: ≥98%

Formula Markup: C22H21ClN2O5

Formula Weight: 428.9

CAS Number: 431979-47-4

Notes: SJ 172550 is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM.{33300} It forms a covalent, but reversible, cysteine adduct in the MDMX p53-binding domain, locking MDMX into a conformation that prevents binding to p53.{33301} SJ 172550 induces apoptosis, increases p53 target gene expression, and causes p53-dependent cell death in retinoblastoma cells.{33300}

• SKU: CAY19999-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19999-5
• Package Unit: 5 mg
• Quantity Unit: STK