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Encompassing Amino Acids: 92-707(end)
Background: Skd3 is a mitochondrial AAA ATPase protein that acts as a chaperone. It uses ATP hydrolysis to chaperone protein unfolding and disassembly, and to reverse protein aggregation. Sdk3 also plays a role in apoptosis by solubilizing HAX1 (HCLS-associated protein X-1). Mutations lead to metabolic disorders characterized by neutropenia, 3-methylglutaconic aciduria and developmental delays. Interestingly, Skd3 has been linked to Venetoclax resistance in the treatment of acute myeloid leukemia (AML), revealing its importance in AML therapy.
Description: Recombinant human Skd3 (also known as ClpB, caseinolytic peptidase B protein homolog), encompassing amino acids 92-707(end). This construct contains an MBP (maltose binding protein) tag followed by a TEV protease site and corresponds to the wild-type protein. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 50 mM Tris, pH 8.0, 300 mM KCl, 10% glycerol, 5 mM ATP, 10 mM MgCl2, 3 mM DTT, and 10 mM Maltose
Genbank: NM_030813.6
Host Cell Line: E. coli
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal MBP-Tag
Uniprot: Q9H078
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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