SMBA1, CAS 906440-37-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-[(2-nitro-9H-fluoren-9-ylidene)methyl]-phenol

Purity: ≥98%

Formula Markup: C20H13NO3

Formula Weight: 315.32216

CAS Number: 906440-37-7

Notes: A Bax activator (Ki = 43.3 nM in a fluorescence polarization assay); selectively reduces viability in wild-type but not Bax-/- MEFs at 25 µM; inhibits nicotine-induced increases in phosphorylated Bax levels in A549 cells at 5 µM; reduces viability in A549 cells at 5 µM; induces cell cycle arrest at the G2/M phase in U87MG cells at 5, 10, or 15 µM; disrupts the mitochondrial membrane potential in U87MG cells at 15 µM; induces cytochrome c release from mitochondria and Bax insertion into mitochondrial membranes in A549 cells at 5 or 10 µM; decreases tumor volume in an A549 mouse xenograft model at 40 or 60 mg/kg per day

• SKU: CAY42247-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42247-25
• Package Unit: 25 mg
• Quantity Unit: STK