Product Description: Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization.
Applications: Cancer-Kinase/protease
Formula: C39H67N5O6
References: [1]Yamamoto N, et al. Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks. Cancer Sci. 2009 Feb;100(2):316-21./[2]Fanale D, et al. Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option? Anal Cell Pathol (Amst). 2015;2015:690916./[3]Watanabe K, et al. Blockade of the extracellular signal-regulated kinase pathway enhances the therapeutic efficacy of microtubule-destabilizing agents in human tumor xenograft models. Clin Cancer Res. 2010 Feb 15;16(4):1170-8.
CAS Number: 149606-27-9
Molecular Weight: 701.98
Compound Purity: 99.29
Research Area: Cancer
Solubility: H2O : < 0.1 mg/mL (ultrasonic)
Target: Microtubule/Tubulin
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