Product Description: Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission[1][2][3][4].
Applications: Neuroscience-Neuromodulation
Formula: H2Na6O40W12
References: [1]Wall M J, et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition [J]. Neuropharmacology, 2008, 55(7): 1251-1258./[2]Pimenta-dos-Reis G, et al. POM-1 inhibits P2 receptors and exhibits anti-inflammatory effects in macrophages [J]. Purinergic Signalling, 2017, 13: 611-627./[3]Csóka B, et al. CD39 improves survival in microbial sepsis by attenuating systemic inflammation [J]. The FASEB Journal, 2015, 29(1): 25./[4]Yang R, et al. Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade [J]. Journal for immunotherapy of cancer, 2020, 8(1).
CAS Number: 12141-67-2
Molecular Weight: 2986.01
Research Area: Cancer; Inflammation/Immunology; Neurological Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)
Target: Interleukin Related;P2X Receptor;P2Y Receptor;Phosphatase;Pyroptosis
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