SR 1078, CAS 1246525-60-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)-benzamide

Purity: ≥98%

Formula Markup: C17H10F9NO2

Formula Weight: 431.3

CAS Number: 1246525-60-9

Notes: Retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ) have been demonstrated to play important roles in the regulation of metabolism, circadian rhythms, immune function, and tumorigenesis. SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 µM without effect at the related liver X receptors and farnesoid X receptors.{26889} At 5 µM, SR 1078 has been shown to stabilize p53 and to induce apoptosis in HepG2 cancer cells.{26890}

• SKU: CAY16503-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16503-1
• Package Unit: 1 mg
• Quantity Unit: STK