SR12418, CAS 1801185-08-9

Product Description: SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research[1][2].

Applications: COVID-19-immunoregulation

Formula: C31H30FNO3

References: [1]Mohammed Amir, et al. REV-ERBα Regulates TH17 Cell Development and Autoimmunity. Cell Rep. 2018 Dec 26;25(13):3733-3749.e8./[2]Shuai Wang, et al. Targeting REV-ERBα for therapeutic purposes: promises and challenges. Theranostics. 2020 Mar 4;10(9):4168-4182.

CAS Number: 1801185-08-9

Molecular Weight: 483.57

Compound Purity: 99.93

Research Area: Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: REV-ERB

• SKU: MEXHY-148103-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-148103-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK