SU11274, CAS 658084-23-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide

Purity: ≥95%

Formula Markup: C28H30ClN5O4S

Formula Weight: 568.1

CAS Number: 658084-23-2

Notes: MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.{23657} Dysregulation of c-Met occurs in many types of cancer.{23657} SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM).{23656} It has much less or no activity against other receptor tyrosine kinases.{23656} SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.{23656,23655}

• SKU: CAY14861-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 14861-500
• Package Unit: 500 µg
• Quantity Unit: STK