Product Description: Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
Applications: Neuroscience-Neuromodulation
Formula: C63H98N18O13S
Citations: Authorea. 2023 Aug 14./Cell Discov. 2023 Jun 30;9(1):66./Cell Prolif. 2019 Jan;52(1):e12527./Chin J Comp Med. May 2018,Vol. 28. No. 5/Eur J Pharmacol. 2023 Jul 6;175902./Free Radic Biol Med. 2023 Oct 5;209(Pt 1):1-8./Immunol Lett. 2024 Oct 10:106934./Int J Biol Sci. 2024 Apr 22;20(7):2507-2531./iScience. 2023 Apr 13./J Am Soc Mass Spectrom. 2020 Jul 5./J Headache Pain. 2024 Aug 28;25(1):141./J Immunol Res. 2022 May 12;2022:5582811./J Invest Dermatol. 2022 Nov 18;S0022-202X(22)02770-1./Mol Biol Rep. 2022 Jan 16./Prog Neurobiol. 2021 Mar 22;102041./Research Square Preprint. 2021 Dec./Research Square Preprint. 2021 Jul./Research Square Preprint. 2021 Sep./Mol Med Rep. December 13, 2021.
References: [1]Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24./[2]Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527.
CAS Number: 33507-63-0
Molecular Weight: 1347.63
Compound Purity: 99.82
Research Area: Neurological Disease; Endocrinology; Cancer
Solubility: H2O : ≥ 20 mg/mL
Target: Endogenous Metabolite;Neurokinin Receptor
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