Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-amino-N-2-pyrimidinyl-benzene-2,3,5,6-d4-sulfonamide
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C10H6D4N4O2S
Formula Weight: 254.3024
CAS Number: 1020719-78-1
Notes: Sulfadiazine-d4 is intended for use as an internal standard for the quantification of sulfadiazine (Item No. 23719) by GC- or LC-MS. Sulfadiazine is a sulfonamide antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria.{38582,36439,36440,36441} It inhibits dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA; Item No. 18659) to dihydropteroate, an intermediate in folate biosynthesis.{38582} Sulfadiazine inhibits recombinant P. carinii DHPS (IC50 = 0.19 μM). It is active against clinical isolates of M. tuberculosis (MIC90 = 10 mg/L) and of N. meningitidis (MICs = 5-2,000 mg/L).{36439,36440} Sulfadiazine is also active against A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90s = 16473).{36441} In vivo, sulfadiazine (40 mg/kg per day) increases survival in a mouse model of lethal T. gondii infection when administered in combination with pyrimethamine (Item No. 16472).{36442} Formulations containing sulfadiazine have been used in the treatment of rheumatic fever and various infections, and, in a dual treatment with pyrimethamine, to treat toxoplasmosis.
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