Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl-d3)phenyl]methylene]-1H-indene-3-acetic acid
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C20H14D3FO3S
Formula Weight: 359.429763
Notes: Sulindac-d3 is intended for use as an internal standard for the quantification of sulindac (Item No. 10004386) by GC- or LC-MS. Sulindac is a non-steroidal anti-inflammatory drug (NSAID), selective COX-2 inhibitor (IC50s = 0.79 and >1,000 µM for COX-2 and COX-1, respectively), and prodrug form of sulindac sulfide (Item No. 10004387).{59800,39154,59801,59802} Sulindac is reduced by intestinal bacteria to form sulindac sulfide.{59800} It inhibits acetic acid-induced writhing in mice and reduces paw edema induced by carrageenan in rats when administered at a dose of 100 mg/kg.{59801} Sulindac (60 mg/kg) reduces tumor growth in MiaPaCa-2 and BxPC-3 mouse xenograft models.{59802} Formulations containing sulindac have been used in the treatment of pain associated with arthritis, ankylosing spondylitis, and gout.
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