Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5-fluoro-2-methyl-1Z-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid
Purity: ≥98%
Formula Markup: C20H17FO2S
Formula Weight: 340.4
CAS Number: 49627-27-2
Notes: Sulindac sulfide is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor sulindac (Item No, 10004386).{27308,27307} It inhibits both COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively), whereas the parent compound, sulindac, is much less effective (IC50 = 58 µM for COX-2 and > 100 µM for COX-1).{8427} Sulindac sulfide also inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications.{27311} It increases the expression and activity of NAD(P)H quinone oxidoreductase 1.{27309} Sulindac sulfide inhibits colorectal cancer growth both in vitro and in vivo.{27312}
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