SW157765, CAS 332063-87-3

Product Description: SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].

Applications: Cancer-programmed cell death

Formula: C19H13N3O3

References: [1]Pine SR, et al. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018;7(Suppl 3):S265-S269./[2]McMillan EA, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018;173(4):864-878.e29.

CAS Number: 332063-87-3

Molecular Weight: 331.32

Compound Purity: 98.67

Research Area: Cancer

Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target: GLUT

• SKU: MEXHY-139047-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-139047-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK