T2AA, CAS 1380782-27-3

Product Description: T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1].

Applications: Cancer-programmed cell death

Formula: C15H15I2NO3

References: [1]Akira Inoue, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014 Mar 7;289(10):7109-7120.

CAS Number: 1380782-27-3

Molecular Weight: 511.09

Compound Purity: 98.03

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: DNA/RNA Synthesis

• SKU: MEXHY-110111-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-110111-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK