TA-02, CAS 1784751-19-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[2-(2-fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-pyridine

Purity: ≥98%

Formula Markup: C20H13F2N3

Formula Weight: 333.334246

CAS Number: 1784751-19-4

Notes: TA-02 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 / 13344) and an inducer of cardiomyocyte differentiation.{41744} It is cardiomyogenic, increasing expression of the cardiomyocyte marker NKX2-5 by greater than 2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation at a concentration of 5 μM. TA-02 inhibits casein kinase 1ε (CK1ε) and CK1D and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.

• SKU: CAY24668-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 24668-5
• Package Unit: 5 mg
• Quantity Unit: STK