Tafamidis, CAS 594839-88-0

Transthyretin Dissociation Inhibitor

CAS No.: 594839-88-0.

Molecular Formula: C14H7Cl2NO3.

Molecular Weight: 308,1.

Source: Synthetic.

Purity: >98% (TLC); NMR (Conforms).

Solubility: May be dissolved in DMSO (25 mg/ml, warm).

Appearance: Off-white powder.

PubChem CID: 11001318.

Scientific Background: Tafamidis functions as a chaperone that stabilizes the correctly folded tetrameric form of the transthyretin (TTR) protein by binding in one of the two thyroxine-binding sites of the tetramer (1). In drug form, it is used to delay impairment of peripheral nerve function in adults with familial amyloid polyneuropathy.

References: 1. Said G, Grippon S, Kirkpatrick P. (2012). Nature Reviews. Drug Discovery. 11(3): 185–186.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-584-25MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-584-25MG
• Package Unit: 25 mg
• Quantity Unit: STK