Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4,4-dioxide 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt
Purity: ≥95%
Formula Markup: C10H11N4O5S / Na
Formula Weight: 322.3
CAS Number: 89785-84-2
Notes: Tazobactam is a β-lactamase inhibitor with greater activity against Ambler class A serine penicillinases and class C cephalosporinases, including TEM-1, SHV-1, and P99 (IC50s = 97, 150, and 8.5 nM) than class B metallo-β-lactamases and the class D oxacillinase OXA-1 (IC50s = 400,000 and 1,400 nM, respectively).{27901} However, it also inhibits the class D oxacillinase OXA-2 (IC50 = 10 nM). Tazobactam, in combination with piperacillin, is active against Gram-positive (MIC90s = 2-128 µg/ml) and Gram-negative bacteria (MIC90s = 4-128 µg/ml).{36746} In a neutropenic mouse model of thigh infection, tazobactam potentiates the activity of ceftolozane against Enterobacteriaceae.{36747} Formulations containing tazobactam, alone and in combination with piperacillin, have been used in the treatment of β-lacatamase-producing bacteria.
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