Tenalisib, CAS 1639417-53-0

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-(3-fluorophenyl)-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C23H18FN5O2

Formula Weight: 415.4

CAS Number: 1639417-53-0

Notes: Tenalisib is an inhibitor of PI3Kδ and PI3Kγ (IC50s = 24.5 and 33.2 nM, respectively).{68887} It is greater than 300- and 120-fold selective for PI3Kδ and PI3Kγ, respectively, over PI3Kα and PI3Kβ. Tenalisib (10 µM) induces cell death in L-540, KM-H2, and L-428 Hodgkin lymphoma cells. It induces cell cycle arrest at the G0/G1 phase in the same cells. In vivo, tenalisib reduces tumor growth and vasculature, induces tumor necrosis, and induces the M1 phenotype in tumor-associated macrophages (TAMs) in an L-540 mouse xenograft model.

• SKU: CAY30949-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30949-10
• Package Unit: 10 mg
• Quantity Unit: STK