Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 17-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamide, dihydrochloride
Purity: ≥98%
Formula Markup: C50H66Cl4N8O10S2 / 2HCl
Formula Weight: 1217.97104
CAS Number: 1234365-97-9
Notes: Tenapanor is an orally bioavailable inhibitor of sodium-hydrogen exchanger 3 (NHE-3; IC50 = 10 nM for the recombinant rat protein).{60198} Tenapanor (10 µM) inhibits intestinal fluid absorption in mouse jejunum, but not distal colon, in a closed intestine loop assay.{60199} It also lowers both the sodium and phosphate urinary-to-dietary ratio in a dose-dependent manner in rats.{60198} Tenapanor (5 mg/kg) reverses decreases in stool pellet numbers and water content induced by loperamide (Item No. 14875) and prevents loperamide-induced constipation in mice.{60199} Formulations containing tenapanor have been used in the treatment of irritable bowel syndrome with constipation.
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