Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[[[4-(acetylamino)phenyl]amino]thioxomethyl-4-(1,1-dimethylethyl)]-benzamide
Purity: ≥98%
Formula Markup: C20H23N3O2S
Formula Weight: 369.5
CAS Number: 380315-80-0
Notes: Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells.{16243} Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family.{16243} While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.
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