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Biological Activity: Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 µM, 10 µM, and 67 µM, respectively.
CAS Number: 1011557-82-6
Description: Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 and SIRT2 inhibitor as well as an activator of the p53 pathway. Studies show that Tenovin-6 increases p53 levels more than Tenovin-1 and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SIRT3.
Purity: ≥98% by HPLC
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: SIRTs 1-3
Biosafety Level: Not applicable (BSL-1)
References: McCarthy, A.R, et al. Bioorg Med Chem. 2012 Mar 1;20(5):1779-93.
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