Terreic Acid, CAS 121-40-4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (1R,6S)-3-hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione

Purity: ≥95%

Formula Markup: C7H6O4

Formula Weight: 154.1

CAS Number: 121-40-4

Notes: Terreic acid (TA) is a cell-permeable quinone epoxide that selectively inhibits Bruton’s tyrosine kinase (BTK) catalytic activity (IC50s = 10 and 3 µM for basal and activation levels, respectively).{31003,38003,38004} TA binds to the BTK pleckstrin homology domain (BTK-PH) and blocks the interaction between BTK-PH and PKC (IC50 = 100 µM in human mast cell lysates) without affecting the activity of PKC.{38003,38004} TA has minimal effect on Lyn, Syk, PKA, casein kinase I, ERK1, ERK2, and p38 kinase activities.{38004,38005}

• SKU: CAY10010235-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10010235-1
• Package Unit: 1 mg
• Quantity Unit: STK