Description: This MAb recognizes TGF beta 1, 2 and 3. Three TGF-betas have been identified in mammals. TGF-beta1, TGF-beta2 and TGF-beta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF-beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF-beta3 protein has approximately 80% identity to the mature region of both TGF-beta1 and TGF-beta2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGF-beta's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)
Conjugate: CF740
Concentration: 0.1 mg/mL
Storage buffer: PBS, 0.1% rBSA, 0.05% azide
Clone: 1D11.16.8
Immunogen: Bovine TGF-beta2 protein
Antibody Reactivity: TGF-Beta
References: Note: References for this clone sold by other suppliers may be listed for expected applications.
- Biol Reproduct (1992) 46: 561-572. (IHC, FFPE)
- PLOS ONE 10(7): e0132786. (functional studies)
Entrez Gene ID: 7040 (beta1), 7042 (beta2) & 7043 (beta3)
Expected AB Applications: Functional studies (published for clone)/IHC (FFPE) (published for clone)
Z-Antibody Applications: Functional studies (published)/IHC, FFPE (published)
Antibody Application Notes: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody/Cytokine neutralization or functional assay, order Ab without BSA/azide/Optimal dilution for a specific application should be determined by user
English
Deutsch
