Thalidomide-PEG4-Propargyl, CAS 2098799-77-8

Product Description: Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Applications: Cancer-programmed cell death

Formula: C24H28N2O9

References: [1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11./[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-998.

CAS Number: 2098799-77-8

Molecular Weight: 488.49

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Apoptosis;Autophagy;E3 Ligase Ligand-Linker Conjugates

• SKU: MEXHY-140055-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-140055-1
• Package Unit: 1 mg
• Quantity Unit: STK