Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-(2-((2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)amino)acetamido)-1,11-dioxo-1,4S,4aS,5,5aR,6,11,12aS-octahydrotetracene-2-carboxamide
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C29H30D9N5O8
Formula Weight: 594.7034
CAS Number: 2699607-86-6
Notes: Tigecycline-d9 is intended for use as an internal standard for the quantification of tigecycline (Item No. 15026) by GC- or LC-MS. Tigecycline is a broad-spectrum glycylcycline antibiotic that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth.{22659} It is active against a panel of 1,924 European clinical bacterial isolates including S. aureus, S. epidermidis, S. pneumoniae, E. faecalis, E. faecium, E. coli, K. pneumoniae, P. aeruginosa, and P. mirabilis strains (MICs = In vivo, tigecycline (6.25 mg/kg twice daily for 5 days) decreases levels of C. difficile cytotoxin activity and spore formation in cecum and colon in a mouse model of C. difficile infection.{42396} Formulations containing tigecycline have been used in the treatment of a variety of bacterial infections.
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