Clone Name: 4A16
Application Note: WB: 1:100 - 1:1000. IHC-P: 1:25 - 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 23
Specificity/Sensitivity: This antibody recognizes human TIMP-1 in western blot. No cross-reactivity to human TIMP-2 is noted.
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Uniprot ID: P01033
Antigen Species: Human
Immunogen: Human recombinant TIMP-1 protein
Purification: Protein G purified
Conjugation: Unconjugated
Full Name: TIMP metallopeptidase inhibitor 1
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