Tipifarnib, CAS 192185-72-1

Product Description: Tipifarnib (IND 58359) binds to and inhibits farnesyltransferase (FTase) with an IC50 of 0.86 nM. Antineoplastic activity and antiparasitic activity[1].

Applications: Cancer-programmed cell death

Formula: C27H22Cl2N4O

References: [1]Devendra S Puntambekar, et al. Inhibition of farnesyltransferase: a rational approach to treat cancer? J Enzyme Inhib Med Chem. 2007 Apr;22(2):127-40./[2]End DW, et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 2001 Jan 1;61(1):131-7/[3]Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.

CAS Number: 192185-72-1

Molecular Weight: 489.39578

Compound Purity: 99.89

Research Area: Cancer; Infection

Solubility: DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Farnesyl Transferase

• SKU: MEXHY-10502-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10502-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK