Product Description: Tirbanibulin (dihydrochloride) (Standard) is the analytical standard of Tirbanibulin (dihydrochloride). This product is intended for research and analytical applications. Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
Formula: C26H31Cl2N3O3
References: [1]Lau GM, et al. Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Dig Dis Sci, 2009, 54(7), 1465-1474./[2]Fallah-Tafti A, et al. Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities. Eur J Med Chem, 2011, 46(10), 4853-4858.
CAS Number: 1038395-65-1
Molecular Weight: 504.45
Research Area: Cancer
Target: Microtubule/Tubulin;Reference Standards;Src
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