Tirofiban (hydrochloride monohydrate), CAS 150915-40-5

Product Description: Tirofiban (L700462) hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride monohydrate induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C22H39ClN2O6S

Citations: Front Pharmacol. 2021 Oct 8:12:734603./Mol Divers. 2024 Dec 8.

References: [1]Giordano A, et al. Tirofiban induces VEGF production and stimulates migration and proliferation of endothelial cells. Vascul Pharmacol. 2014 May-Jun;61(2-3):63-71./[2]Liu X, et al. Effects of tirofiban on the reperfusion-related no-reflow in rats with acute myocardial infarction. J Geriatr Cardiol. 2013 Mar;10(1):52-8./[3]Yates YJ, et al. The effect of tirofiban on microvascular thrombosis: crush model. Plast Reconstr Surg. 2005 Jul;116(1):205-8

CAS Number: 150915-40-5

Molecular Weight: 495.07

Compound Purity: 99.99

Research Area: Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Integrin

• SKU: MEXHY-17369-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-17369-5
• Package Unit: 5 mg
• Quantity Unit: STK