Tivantinib, CAS 905854-02-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione

Purity: ≥98%

Formula Markup: C23H19N3O2

Formula Weight: 369.4

CAS Number: 905854-02-6

Notes: Tivantinib is an inhibitor of c-Met (Ki = 0.355 µM).{65028} It is selective for c-Met over a panel of 229 additional kinases at 10 µM. Tivantinib also inhibits tubulin polymerization in a cell-free assay in a concentration-dependent manner.{65029} It is cytotoxic to c-Met-dependent and -independent cancer cell lines when used at concentrations ranging from 0.01 to 1 µM. Tivantinib (200 mg/kg) reduces tumor growth in HT-29, MKN45, and MDA-MB-231 mouse xenograft models.{65028}

• SKU: CAY17135-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17135-5
• Package Unit: 5 mg
• Quantity Unit: STK