TM5441, CAS 1190221-43-2

Product Description: TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2].

Applications: Cancer-programmed cell death

Formula: C21H17ClN2O6

References: [1]Placencio VR, et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10(7):e0133786./[2]Jeong BY, et al. Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model. PLoS One. 2016 Jun 3;11(6):e0157012.

CAS Number: 1190221-43-2

Molecular Weight: 428.82

Compound Purity: 98.32

Research Area: Cancer; Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis;PAI-1

• SKU: MEXHY-101761-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101761-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK