TNFRII, Human (HEK293, hFc)

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Product Description: TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNFRII Protein, Human (HEK293, hFc) is expressed by HEK293 and has a transmembrane region (L23-D257) with hFc tag at the C-terminus[1].

Formula: 7133(Gene_ID)P20333 (L23-D257)(Accession)

References: [1]Wajant H, et, al. Tumor necrosis factorsignaling. Cell Death Differ. 2003 Jan;10(1):45-65./[2]Fotin-Mleczek M, et, al. Apoptoticcrosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteinsand accelerates TNF-R1-dependent activation of caspase-8. J Cell Sci. 2002 Jul1;115(Pt 13):2757-70./[3]Masli S, et, al. Anti-inflammatory effectsof tumour necrosis factor (TNF)-alpha are mediated via TNF-R2 (p75) intolerogenic transforming growth factor-beta-treated antigen-presenting cells.Immunology. 2009 May;127(1):62-72.

Molecular Weight: Approximately 68 kDa

Compound Purity: 96.00

• SKU: MEXHY-P72025-100UG
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P72025-100UG
• Package Unit: 100 μg
• Quantity Unit: STK