Product Description: Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases[1].
Formula: C18H23NO
References: [1]McGavack T H, et al. Newer antihistaminics: III. Some pharmacologic and therapeutic effects of β-(P-methylbenzhydryloxy)-ethyldimethylamine hydrochloride, a derivative of diphenhydramine hydrochloride[J]. Journal of Allergy, 1950, 21(4): 353-370.
CAS Number: 19804-27-4
Molecular Weight: 269.38
Compound Purity: 97.23
Research Area: Inflammation/Immunology; Neurological Disease
Target: Endogenous Metabolite;Histamine Receptor;iGluR
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