Tolcapone, CAS 134308-13-7

COMT inhibitor

Product Type: Inhibitor

CAS No.: 134308-13-7

MolecularFormula: C14H11NO5

Molecular Weight: 273,2

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: Soluble in DMSO (25 mg/ml), or ethanol (25 mg/ml)

Appearance: Yellow powder

PubChem CID: 4659569

Scientific Background: Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes1. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity2. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo3. Inhibits O-methylation of exogenous polyphenols such as EGCG4. Cell permeable.

References: 1.PT Manisto et al. Br. J. Pharmacol. 1992 105:5692.S Di Giovanni et al. J. Biol. Chem. 2010 285:149413.R Sant’Anna et al. Nat. Commun. 2016 7:107874.SC Forester and JD Lambert J. Funct. Foods 2015 17:183

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-540-10MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-540-10MG
• Package Unit: 10 mg
• Quantity Unit: STK