Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl-2,3,5,6-d4)methanone
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C14H7D4NO5
Formula Weight: 277.26512
CAS Number: 1246816-93-2
Notes: Tolcapone-d4 is intended for use as an internal standard for the quantification of tolcapone (Item No. 20768) by GC- or LC-MS. Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT; Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine (Item No. 21992) and L-DOPA (Item No. 13248).{42962,22704} Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity.{32113,22703} By inhibiting COMT, tolcapone increases L-DOPA efficacy and reduces L-DOPA-induced motor complications in animal models of Parkinson’s disease.{32113}
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