Product Description: Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity[1][2].
Applications: Cancer-programmed cell death
Formula: C7H7N5O2
References: [1]Wei W, et al. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer. 2010 May 15;126(10):2426-36./[2]Franci G, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics. 2017 Mar 4;12(3):198-205.
CAS Number: 84-82-2
Molecular Weight: 193.16
Compound Purity: 99.88
Research Area: Cancer; Infection
Solubility: DMSO : 25 mg/mL (ultrasonic)/H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Antibiotic;Bacterial;Histone Demethylase;β-catenin