TP-0472993, CAS 2126874-77-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 1-[4-[[[6-(1H-pyrazol-3-yl)-3-pyridinyl]oxy]methyl]-1-piperidinyl]-ethanone

Purity: ≥98%

Formula Markup: C16H20N4O2

Formula Weight: 300.4

CAS Number: 2126874-77-7

Notes: TP-0472993 is an inhibitor of the cytochrome P450 (CYP) isoforms CYP4A11 and CYP4F2 (IC50s = 140 and 40 nM, respectively).{67824} It is selective for CYP4A11 and CYP4F2 over a panel of eight additional CYPs at 10 µM. TP-0472993 inhibits 20-HETE (Item No. 90030) production in rat renal microsomes (IC50 = 347 nM). In vivo, TP-0472993 (0.03-1 mg/kg) inhibits 20-HETE production in rats. It also reduces renal fibrosis and IL-1β and TNF-α levels in a mouse model of folic acid-induced nephropathy and a mouse model of unilateral ureteral obstruction-induced neuropathy when administered at a dose of 3 mg/kg.{67825}

• SKU: CAY39757-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39757-10
• Package Unit: 10 mg
• Quantity Unit: STK