TP0463518, CAS 1558021-37-6

Product Description: TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C20H18ClN3O6

References: [1]Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144.

CAS Number: 1558021-37-6

Molecular Weight: 431.83

Compound Purity: 98.62

Research Area: Metabolic Disease

Solubility: DMSO : ≥ 125 mg/mL

Target: HIF/HIF Prolyl-Hydroxylase

• SKU: MEXHY-112144-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112144-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK