TPE-MI, CAS 1245606-71-6

Product Description: TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells. TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum [1][2].

Applications: Neuroscience-Neurodegeneration

Formula: C31H23NO2

References: [1]Chen MZ, et al. A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat Commun. 2017;8(1):474. Published 2017 Sep 7. /[2]Hu Q, et al. In Situ Monitored Vortex Fluidic-Mediated Protein Refolding/Unfolding Using an Aggregation-Induced Emission Bioprobe. Molecules. 2021;26(14):4273. Published 2021 Jul 14.

CAS Number: 1245606-71-6

Molecular Weight: 441.52

Compound Purity: 98.71

Research Area: Neurological Disease

Solubility: DMSO : 44.15 mg/mL (ultrasonic)

Target: Huntingtin;Parasite

• SKU: MEXHY-143218-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-143218-10
• Package Unit: 10 mg
• Quantity Unit: STK